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Nexum 20

(Capsule)

Generics: Esomeprazole Magnesium Trihydrate 20mg


Square Pharmaceuticals Ltd


price/7.00 tk

Symptoms

Treatment of chronic heartburn, GERD symptoms, erosive esophagitis, duodenal ulcer, Zollinger-Ellison Syndrome, and acid dyspepsia-related duodenal and gastric ulcers


Pharmacology

Esomeprazole inhibits gastric acid output by suppressing the H+/K+-ATPase in gastric parietal cells; provides superior acid control compared to racemic proton pump inhibitors


Dosage

The recommended dosage for Nexum 20 Capsule varies based on the condition being treated. For healing erosive esophagitis, the initial dose is 20 mg or 40 mg once daily for 4-8 weeks, with maintenance at 20 mg once daily thereafter. Symptomatic GERD is treated with 20 mg once daily for 4 weeks. Helicobacter pylori eradication involves a 10-day triple therapy with esomeprazole 40 mg once daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily. Zollinger-Ellison Syndrome requires 20-80 mg once daily, adjusted individually. Acid-related dyspepsia is managed with 20-40 mg once daily for 2-4 weeks, while duodenal ulcer is treated with 20 mg once daily for 2-4 weeks. For gastric ulcer, the dosage is 20-40 mg once daily for 4-8 weeks. Additionally, the injection form is recommended at 40 mg once daily by intravenous administration. Safety in pediatric patients has not been established.


Interaction

Esomeprazole may interact with drugs metabolized by CYP2C19 and CYP3A4; no significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin observed


Contraindications

Hypersensitivity to any formulations of esomeprazole


Side Effects

Common side effects include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth


Pregnancy & Lactation

Limited well-controlled trials in pregnant women; no teratogenic effects found in animal studies; excretion in milk not studied; breastfeeding should be terminated if esomeprazole use is deemed necessary


Precautions & Warnings

Symptomatic response to Nexum 20 does not rule out the possibility of gastric cancer; esomeprazole pills should be taken at least one hour before meals


Therapeutic Class

Proton Pump Inhibitor


Storing Condition

Store in a dry location at a temperature not exceeding 30°C; avoid light and dampness; keep out of children's reach


Pharmaceutical Name

Square Pharmaceuticals Ltd.